ea0050s2.3 | When receptors go rogue | SFEBES2017
Levin Ellis
Steroid receptors (SR) respond to binding of their ligands with rapid signal transduction resulting from engaging extra-nuclear receptors. This occurs in addition to the conventional aspects of steroids/nuclear SR that regulate gene transcription. In breast cancer, estrogen and progesterone receptors (ER, PR) are present at the plasma membrane in addition to the nucleus. Here the receptors activate many pathways as G-protein coupled receptors, resulting in epigenetic and genet...